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Deze overeenkomst betekent dat de serotoninereceptoren ook reageren op psilocine. Bij het innemen van een magic truffel of paddenstoel, Tsunami's van serotonine-achtige stoffen komen vrij in het cerebellum. Psilocine bindt zich aan de receptoren, wat zich op zijn beurt vertaalt in de hierboven beschreven effecten.
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Bewaar magische truffels in de koelkast bij een temperatuur van two-four°C. Zorg ervoor dat ze in een luchtdichte verpakking zitten om uitdroging te here voorkomen. Zo blijven ze enkele weken vers.
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